… In this Review, we explore the literature regarding ion channel signalling in the context of
regulating mammalian sperm motility and male fertility, focusing on sperm ion channels and …

… acquisition, maintenance, and modulation are essential for male fertility. The first steps of …
found to positively regulate sperm activation (T-type) and total and progressive motility (L-type) […

… 293B showed lower sperm motility and progressive motility. … These potassium channels
may be able to help compensate if … channel in human sperm, its role in genetic male infertility …

… the capacity for motility (3); progressive motility is initiated … beating of flagella resulting in
progressive motility (4). This is … sperm motility may be important in addressing male infertility …

… reproduction technology (ART) as well [4,5,6,7,8,9,10,11]. However, the diagnosis of male
infertility remains mainly based on semen … morphology and progressive motility but were …

… ical reactions, eg, progressive motility, hyperactivation, required for successful fertilization. …
ion channel proteins are required for male fertility and sperm cell hyperactivated motility. …

… Sperm function is highly dependent on the exchange of ions … This is under the control of a
series of ion channels, … of flagellar beat, including progressive motility, straight line, curvilinear …

… type of motile cilium required for sperm motility and male fertility. … motility, which can lead
to infertility [7,8]. In this review, we summarize recent advances in the function of ion channels …

… (K + ), sodium (Na + ), chloride (Cl − ) and hydrogen (H + ) are also relevant to male fertility,
since they are implicated in the regulation of internal pH (pH i ) and/or the plasma membrane …

… plasma decreases sperm motility and that Zn 2+ removal enhances motility. Reduction in …
of progressive motility and the subsequent hyper activated motility during sperm capacitation. …